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Title |
Controllable One-Pot Synthesis for Scaffold Diversity via Visible-Light Photoredox-Catalyzed Giese Reaction and Further Transformation |
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Author list |
Nam, Su Been, Khatun, Nilufa, Kang, Young Woo, Park, Boyoung Y. and Woo, Sang Kook |
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Publication date |
2020/03 |
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Citation information |
Chemical Communications, 56, 2873 (2020) |
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DOI |
10.1039/C9CC08781H |
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Graphical Abstract |
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Abstract |
This study presents a controllable one-pot synthesis for constructing valuable scaffolds (alcohols, 2,3-dihydrofurans, ?-cyano-γ-butyrolactones, and γ-butyrolactones) via a visible-light photoredox-catalyzed Giese reaction and further transformation. This one-pot reaction can selectively synthesize the desired scaffold in excellent yields with good functional group tolerance. To further highlight the broad applicability of this controllable one-pot reaction, we have established flow reaction conditions with short reaction times for the scale-up of each scaffold and demonstrated the further transformation of 2,3-dihydrofurans and ?-cyano-γ-butyrolactones to achieve scaffold diversity for applications in drug discovery. | |
